Many medications may have anticholinergic effects and interaction between Polypharmacy overdoses may make the anticholinergic toxidrome less apparent. Discussions of specific agents that can cause an anticholinergic toxidrome and the general approach to the poisoned patient are found. Anticholinergic Syndrome. Anticholinergic Syndrome. by Chris Nickson, Last updated January 13, AGENTS. anti-histamines; anti-parkinsonians.

Author: Kazahn Tygogis
Country: Algeria
Language: English (Spanish)
Genre: Business
Published (Last): 8 June 2011
Pages: 110
PDF File Size: 7.2 Mb
ePub File Size: 20.71 Mb
ISBN: 632-6-31775-524-4
Downloads: 66056
Price: Free* [*Free Regsitration Required]
Uploader: Dim

The characteristic feature of toxicity at central receptors is agitated delirium.

Anticholinergic Syndrome

These children often benefit from 1-to-1 nursing. Peripheral inhibition is variable – but the symptoms may include: Complications include hypertensiontachycardiaand tachypnea. This page was last edited on 31 Octoberat The Royal Children’s Toxidrom Melbourne.

Referral to local mental health services e. Likewise, recreational poisonings with anticholinergic botanicals are common in adolescents. The symptoms of an anticholinergic toxidrome include blurred vision, comadecreased bowel sounds, deliriumdry skinfeverflushinghallucinationsileusmemory lossmydriasis dilated pupilsmyoclonuspsychosisseizuresand urinary retention.

Clinical Practice Guidelines : Anticholinergic Syndrome

While most sedative-hypnotics are anticonvulsantsome such as GHB and methaqualone instead lower the seizure threshold, and so can cause paradoxical seizures in overdose.

Substances that may cause this toxidrome include carbamatesmushroomsand organophosphates. Pediatric toxidrome simulation curriculum: Diphenhydramine, Doxylamine, Promethazine, Chlorpheniramine, Cyproheptadine.


To view all publication components, extract i. Some cough medications may also contain paracetamol – so a concentration should be considered in anticholinwrgic accidental ingestions as well.

Anticholinergic Toxidrome • LITFL

Other scenarios do exist, but they lack the detailed preparatory material, potential mistakes, and supplemental educational materials provided here. Complications include hypertensionhyperthermiaand tachycardia.

Views Read Edit View history. There exists some controversy over the use of physostigmine – a cholinesterase inhibitor – which has been used to reduce delirium in anticholinergic syndrome. Anticholinergid information and follow-up: Substances that may cause this toxidrome include salbutamolamphetaminescocaineephedrine Ma Huangmethamphetaminephenylpropanolamine PPA’sand pseudoephedrine.

Serotonin syndrome Toxidroms malignant syndrome Malignant hyperthermia Salicylate toxicity Non-toxicological causes may include: Dry mouth, dry eyes and decreased sweating “Mad as a hatter”: Parent information sheet from Victorian Poisons Information centre on anticholinerhic prevention of poisoning. Complications include bradycardiahypothermiaand tachypnea. Normal GCS Normal ECG Ensure provision for safe discharge are in place In cases of deliberate ingestion, a risk assessment should indicate that the child or young person is at low risk of further self harm in the discharge setting.

If anticholinergic syndrome is suspected please seek senior advice and discuss with toxicologist. Encephalitis Sepsis Neurotrauma Post-ictal phenomena Hypoglycaemia Hyponatraemia Behavioural disturbance Investigations Screening tests – 12 lead ECG, blood glucose antichklinergic paracetamol concentration – in deliberate self-poisoning.


The features of otxidrome at peripheral and central receptors can be remembered using the following anticholinerrgic “Hot as a hare”: Substances that may cause this toxidrome include anticonvulsantsbarbituratesbenzodiazepinesgamma-Hydroxybutyric acidMethaqualoneand ethanol.

This publication predates our implementation of the Educational Summary Report in and thus displays a different format than newer publications. It may anticholinergif very similar to the anticholinergic toxidrome, but is distinguished by hyperactive bowel sounds and sweating. Attention should be paid to the maintenance of airway, breathing and circulation.

Your email address will not be published. This curriculum is the most comprehensive pediatric anticholinergic toxidrome curriculum we have seen. The symptoms of a sympathomimetic toxidrome include anxietydelusionsdiaphoresishyperreflexiamydriasisparanoiapiloerectionand seizures.

Bladder scan will reveal the need for a urinary catheter. Substances that may cause this toxidrome include substituted amphetaminescocaineand phencyclidine. Recognize and hoxidrome anticholinergic toxidrome in a safe and professional manner.