Eurand’s Diffucaps® technology enables the development of once-daily controlled-release (CR) capsules or patient-friendly orally disintegrating tablet ( ODT). Download scientific diagram | ORBEXA ® Technology 3) DIFFUCAPS ® Technology: Diffucaps is a multiparticulate bead system comprised of multiple layers of. DIFFUCAPS ® technology 4) DIFFUTAB ® Technology: Diffutab technology enables customized release profiles and region-specific delivery. Diffutab.

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European Journal of Pharmaceutical Sciences ; Due to their high efficiency and lack of undesirable adverse effects to the whole body, the stimuli-responsive feature of these systems is useful for treatment of patients.

Chen H, Langer R.

9. Pulsatile Drug Delivery System: Method and Technology Review

Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device. Multiparticulate drug delivery systems for controlled release. A drug core granulated or layered onto a neutral surface is created, followed by the application of one or more rate-controlling, functional polymer membranes.

When the capsule comes in contact with dissolution fluid, the plug gets swells, and after a lag time, the plug pushes itself outside the capsule and rapidly releases the drug.

This review covers methods and marketed technologies that have been developed to achieve pulsatile delivery.

Traditionally, drugs are released in an immediate or extended manner. Advantages of this multiparticulate system are its suitability for drugs exhibiting poor solubility in lower intestinal pH, in environments with a pH above 8. These systems consist of an outer release controlling water insoluble but permeable coating subject to mechanically induced rupture phenomenon.


Diffucaps Customized Release Technology from Adare Pharmaceuticals

When it comes in contact with aqueous fluids, the cap rapidly dissolves thereby releasing the immediate release component followed by pulsed release component. A delay of drug action may be required for a variety of reasons.

Available in both mg and mg tablets, Covera-HS is designed for oral dosing at bedtime. Migration inhibiting additives were effective in limiting transport.

This device consists of a non-disintegrating half capsule body sealed at the open end with a hydrogel plug that is covered by a water-soluble cap. In this case, degradation take places throughout the polymer sample and proceeds technoloy a critical molecular weight is reached. Formulation and in vitro evaluation of floating pulsatile tablets of nizatidine for chronotherpy of ulcers ; 4 5: The lag time can be tecunology by varying coating thickness or adding high amounts of lipophilic plasticizer in the outermost layer4, 8, 9,11,13,14,15,16, World Patent ; Pharmceutical Development and Technology ; 15 2: Time Controlled system 1.

The Time Clock system consists of a solid dosage form coated with lipid barriers containing carnauba wax and bees wax along with surfactants.

This technology is designed to easily divisible tablets in exact smaller doses, thus dosage adjustment become easy.


The lag time is essential for drugs that undergo degradation in gastric acidic medium e.

9. Pulsatile Drug Delivery System: Method and Technology Review | Insight Medical Publishing

Eurand applied this technology to both soluble and insoluble products. Tablets with controlled-rate release tecbnology active substances. The inflamed responsive cells produce hydroxyl radicals. One of the common characteristics of temperature-sensitive polymers is the presence of hydrophobic groups, such as methyl, ethyl and propyl groups.

Many weakly basic drugs exhibit pH-dependent solubility profiles. A nanoshell when absorb the near-infrared light and convert it to heat and then temperature of composite hydro gel is raised above its lower critical solution temperature LCST. Positive thermosensitive pulsatile drug release using negative thermosensitive hydrogels.

In these systems, the drug is released after stimulation by any biological factor, like temperature technlogy any other chemical stimuli. Thus, the major challenge in the development of pulsatile drug delivery system is to achieve a rapid diffucapss release after the lag time.

An electric field as an external stimulus has advantages, such as availability of equipment that allows precise control with regard to the magnitude of the current, duration of electric pulses, interval between pulses, etc.